Penetration of Nanobody-Dextran Polymer Conjugates through Tumor Spheroids

• Main Authors: Peter Bitsch (Author), Eva S. Baum (Author), Irati Beltrán Hernández (Author), Sebastian Bitsch (Author), Jakob Harwood (Author), Sabrina Oliveira (Author), Harald Kolmar (Author)
• Format: Book
• Published: MDPI AG, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Here we report the generation of nanobody dextran polymer conjugates (dextraknobs) that are loaded with small molecules, i.e., fluorophores or photosensitizers, for potential applications in cancer diagnostics and therapy. To this end, the molecules are conjugated to the dextran polymer which is cou...