Cumulative inactivated vaccine exposure and allergy development among children: a birth cohort from Japan

• Main Authors: Kiwako Yamamoto-Hanada (Author), Kyongsun Pak (Author), Mayako Saito-Abe (Author), Limin Yang (Author), Miori Sato (Author), Hidetoshi Mezawa (Author), Hatoko Sasaki (Author), Minaho Nishizato (Author), Mizuho Konishi (Author), Kazue Ishitsuka (Author), Kenji Matsumoto (Author), Hirohisa Saito (Author), Yukihiro Ohya (Author), Japan Environment and Children's Study (JECS) (Author)
• Format: Book
• Published: Komiyama Printing Co. Ltd, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Adjuvants used in inactivated vaccines often upregulate type 2 immunity, which is dominant in allergic diseases. We hypothesised that cumulative adjuvant exposure in infancy may influence the development of allergies later in life by changing the balance of type 1/type 2 immunity...