Sorafenib-Induced Autophagy Promotes Glycolysis by Upregulating the p62/HDAC6/HSP90 Axis in Hepatocellular Carcinoma Cells

• Main Authors: Xiaoyu Yan (Author), Rui Tian (Author), Jicheng Sun (Author), Yuanxin Zhao (Author), Buhan Liu (Author), Jing Su (Author), Minghua Li (Author), Wei Sun (Author), Xuesong Xu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sorafenib has attracted much attention as the first drug approved by the FDA for the treatment of advanced hepatocellular carcinoma (HCC). Because of the drug tolerance, the overall outcomes were far from satisfactory. Current studies suggest that changes in glucose metabolism induced by sorafenib a...