Tacrolimus pharmacokinetics are influenced by CYP3A5, age, and concomitant fluconazole in pediatric kidney transplant patients

• Asıl Yazarlar: Alaa Alghamdi (Yazar), Sarah Seay (Yazar), David K. Hooper (Yazar), Charles D. Varnell Jr (Yazar), Leanna Darland (Yazar), Tomoyuki Mizuno (Yazar), Danielle Lazear (Yazar), Laura B. Ramsey (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Wiley, 2023-10-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Abstract Tacrolimus, the most common immunosuppressant for organ transplant, has a narrow therapeutic range and is metabolized by CYP3A4/5. Trough concentration monitoring and dosing adjustments are used to reach a therapeutic range. CYP3A5 intermediate and normal metabolizers (*1 allele carriers; I...