Tacrolimus pharmacokinetics are influenced by CYP3A5, age, and concomitant fluconazole in pediatric kidney transplant patients

• Main Authors: Alaa Alghamdi (Author), Sarah Seay (Author), David K. Hooper (Author), Charles D. Varnell Jr (Author), Leanna Darland (Author), Tomoyuki Mizuno (Author), Danielle Lazear (Author), Laura B. Ramsey (Author)
• Format: Book
• Published: Wiley, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Tacrolimus, the most common immunosuppressant for organ transplant, has a narrow therapeutic range and is metabolized by CYP3A4/5. Trough concentration monitoring and dosing adjustments are used to reach a therapeutic range. CYP3A5 intermediate and normal metabolizers (*1 allele carriers; I...