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Loss of KEAP1 Causes an Accumulation of Nondegradative Organelles

KEAP1 is a cytoplasmic protein that functions as an adaptor for the Cullin-3-based ubiquitin E3 ligase system, which regulates the degradation of many proteins, including NFE2L2/NRF2 and p62/SQSTM1. Loss of KEAP1 leads to an accumulation of protein ubiquitin aggregates and defective autophagy. To be...

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Main Authors: Elisabet Uribe-Carretero (Author), Guadalupe Martinez-Chacón (Author), Sokhna M. S. Yakhine-Diop (Author), Gema Duque-González (Author), Mario Rodríguez-Arribas (Author), Eva Alegre-Cortés (Author), Marta Paredes-Barquero (Author), Saray Canales-Cortés (Author), Elisa Pizarro-Estrella (Author), Antonio Cuadrado (Author), Rosa Ana González-Polo (Author), José M. Fuentes (Author), Mireia Niso-Santano (Author)
Format: Book
Published: MDPI AG, 2022-07-01T00:00:00Z.
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