The Forefront for Novel Therapeutic Agents Based on the Pathophysiology of Lower Urinary Tract Dysfunction: Bladder Selectivity Based on In Vivo Drug-Receptor Binding Characteristics of Antimuscarinic Agents for Treatment of Overactive Bladder

• Egile Nagusiak: Akira Yoshida (Egilea), Tomomi Fujino (Egilea), Shuji Maruyama (Egilea), Yoshihiko Ito (Egilea), Yuko Taki (Egilea), Shizuo Yamada (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2010-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

We have reviewed the binding of antimuscarinic agents, used to treat urinary dysfunction in patients with overactive bladder, to muscarinic receptors in target and non-target tissues in vivo. Transdermal administration of oxybutynin in rats led to significant binding in the bladder without long-term...