Downregulation of HMGB1 carried by macrophage-derived extracellular vesicles delays atherosclerotic plaque formation through Caspase-11-dependent macrophage pyroptosis

• Autori principali: Weijie Liang (Autore), Ruibin Wei (Autore), Xingxing Zhu (Autore), Jinliang Li (Autore), Aiwen Lin (Autore), Jun Chen (Autore), Wen Wu (Autore), Qiang Jie (Autore)
• Natura: Libro
• Pubblicazione: BMC, 2024-03-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Abstract Background Macrophage-derived extracellular vesicle (macrophage-EV) is highly studied for its regulatory role in atherosclerosis (AS). Our current study tried to elucidate the possible role of macrophage-EV loaded with small interfering RNA against high-mobility group box 1 (siHMGB1) affect...