Reduced Levels of H₂S in Diabetes-Associated Osteoarthritis Are Linked to Hyperglycaemia, Nrf-2/HO-1 Signalling Downregulation and Chondrocyte Dysfunction

• Main Authors: María Piñeiro-Ramil (Author), Elena F. Burguera (Author), Tamara Hermida-Gómez (Author), Beatriz Caramés (Author), Natividad Oreiro-Villar (Author), Rosa Meijide-Faílde (Author), Francisco J. Blanco (Author), Carlos Vaamonde-García (Author)
• Format: Book
• Published: MDPI AG, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Different findings indicate that type 2 diabetes is an independent risk factor for osteoarthritis (OA). However, the mechanisms underlying the connection between both diseases remain unclear. Changes in the balance of hydrogen sulphide (H₂S) are thought to play an important ro...