Discovery of new antimicrobial thiophene derivatives with activity against drug-resistant Gram negative-bacteria

• Hoofdauteurs: Irene Molina-Panadero (Auteur), Marcos Morales-Tenorio (Auteur), Alfonso García-Rubia (Auteur), Tiziana Ginex (Auteur), Khalil Eskandari (Auteur), Ana Martinez (Auteur), Carmen Gil (Auteur), Younes Smani (Auteur)
• Formaat: Boek
• Gepubliceerd in: Frontiers Media S.A., 2024-08-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Our aim is to identify new small molecules with antimicrobial potential, especially against colistin-resistant (Col-R) Acinetobacter baumannii and Escherichia coli. After initial hits identification by fingerprint similarity, MIC of 24 heterocyclic derivatives for A. baumannii and E. coli reference...