Discovery of new antimicrobial thiophene derivatives with activity against drug-resistant Gram negative-bacteria

• Main Authors: Irene Molina-Panadero (Author), Marcos Morales-Tenorio (Author), Alfonso García-Rubia (Author), Tiziana Ginex (Author), Khalil Eskandari (Author), Ana Martinez (Author), Carmen Gil (Author), Younes Smani (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Our aim is to identify new small molecules with antimicrobial potential, especially against colistin-resistant (Col-R) Acinetobacter baumannii and Escherichia coli. After initial hits identification by fingerprint similarity, MIC of 24 heterocyclic derivatives for A. baumannii and E. coli reference...