Lack of whey acidic protein (WAP) four-disulfide core domain protease inhibitor 2 (WFDC2) causes neonatal death from respiratory failure in mice

• Main Authors: Kuniko Nakajima (Author), Michio Ono (Author), Uroš Radović (Author), Selma Dizdarević (Author), Shin-ichi Tomizawa (Author), Kazushige Kuroha (Author), Go Nagamatsu (Author), Ikue Hoshi (Author), Risa Matsunaga (Author), Takayuki Shirakawa (Author), Takeyuki Kurosawa (Author), Yasunari Miyazaki (Author), Masahide Seki (Author), Yutaka Suzuki (Author), Haruhiko Koseki (Author), Masataka Nakamura (Author), Toshio Suda (Author), Kazuyuki Ohbo (Author)
• Format: Book
• Published: The Company of Biologists, 2019-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Respiratory failure is a life-threatening problem for pre-term and term infants, yet many causes remain unknown. Here, we present evidence that whey acidic protein (WAP) four-disulfide core domain protease inhibitor 2 (Wfdc2), a protease inhibitor previously unrecognized in respiratory disease, may...