Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy

• Main Authors: Lalage A. Katunga (Author), Preeti Gudimella (Author), Jimmy T. Efird (Author), Scott Abernathy (Author), Taylor A. Mattox (Author), Cherese Beatty (Author), Timothy M. Darden (Author), Kathleen A. Thayne (Author), Hazaim Alwair (Author), Alan P. Kypson (Author), Jitka A. Virag (Author), Ethan J. Anderson (Author)
• Format: Book
• Published: Elsevier, 2015-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Lipid peroxides and their reactive aldehyde derivatives (LPPs) have been linked to obesity-related pathologies, but whether they have a causal role has remained unclear. Glutathione peroxidase 4 (GPx4) is a selenoenzyme that selectively neutralizes lipid hydroperoxides, and human gpx4 gen...