Correlation of functional and radioligand binding characteristics of GPER ligands confirming aldosterone as a GPER agonist

• Main Authors: Qingming Ding (Author), Jozef Chorazyczewski (Author), Robert Gros (Author), Harvey J. Motulsky (Author), Lee E. Limbird (Author), Ross D. Feldman (Author)
• Format: Book
• Published: Wiley, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Aldosterone exerts some of its effects not by binding to mineralocorticoid receptors, but rather by acting via G protein‐coupled estrogen receptors (GPER). To determine if aldosterone binds directly to GPER, we studied the ability of aldosterone to compete for the binding of [3H] 2‐methoxye...