Correlation of functional and radioligand binding characteristics of GPER ligands confirming aldosterone as a GPER agonist

• Autors principals: Qingming Ding (Autor), Jozef Chorazyczewski (Autor), Robert Gros (Autor), Harvey J. Motulsky (Autor), Lee E. Limbird (Autor), Ross D. Feldman (Autor)
• Format: Llibre
• Publicat: Wiley, 2022-10-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Abstract Aldosterone exerts some of its effects not by binding to mineralocorticoid receptors, but rather by acting via G protein‐coupled estrogen receptors (GPER). To determine if aldosterone binds directly to GPER, we studied the ability of aldosterone to compete for the binding of [3H] 2‐methoxye...