Lipoteichoic Acids Are Essential for Pneumococcal Colonization and Membrane Integrity

• Main Authors: Max Brendel (Author), Thomas P. Kohler (Author), Janine V. Neufend (Author), Astrid Puppe (Author), Nicolas Gisch (Author), Sven Hammerschmidt (Author)
• Format: Book
• Published: Karger Publishers, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: The hydrophilic, polymeric chain of the lipoteichoic acid (LTA) of the Gram-positive pathobiont Streptococcus pneumoniae is covalently linked to the glycosylglycerolipid α-d-glucopyranosyl-(1,3)-diacylglycerol by the LTA ligase TacL, leading to its fixation in the cytoplasmic membrane....