pTDP‐43 aggregates accumulate in non‐central nervous system tissues prior to symptom onset in amyotrophic lateral sclerosis: a case series linking archival surgical biopsies with clinical phenotypic data

• Main Authors: Samuel B Pattle (Author), Judi O'Shaughnessy (Author), Owen Kantelberg (Author), Olivia M Rifai (Author), Judith Pate (Author), Kristine Nellany (Author), Nadine Hays (Author), Mark J Arends (Author), Mathew H Horrocks (Author), Fergal M Waldron (Author), Jenna M Gregory (Author)
• Format: Book
• Published: Wiley, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Neurodegenerative diseases such as Parkinson's disease (PD), Alzheimer's disease (AD), and amyotrophic lateral sclerosis (ALS) are traditionally considered strictly neurological disorders. However, clinical presentation is not restricted to neurological systems, and non‐central ne...