Systemic Oxidative Stress and Visceral Adipose Tissue Mediators of NLRP3 Inflammasome and Autophagy Are Reduced in Obese Type 2 Diabetic Patients Treated with Metformin

• Main Authors: Zaida Abad-Jiménez (Author), Sandra López-Domènech (Author), Rubén Díaz-Rúa (Author), Francesca Iannantuoni (Author), Segundo Ángel Gómez-Abril (Author), Dolores Periañez-Gómez (Author), Carlos Morillas (Author), Víctor M. Víctor (Author), Milagros Rocha (Author)
• Format: Book
• Published: MDPI AG, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Obesity is a low-grade inflammatory condition affecting a range of individuals, from metabolically healthy obese (MHO) subjects to type 2 diabetes (T2D) patients. Metformin has been shown to display anti-inflammatory properties, though the underlying molecular mechanisms are unclear. To study whethe...