Similar but distinct: The impact of biomechanical forces and culture age on the production, cargo loading, and biological efficacy of human megakaryocytic extracellular vesicles for applications in cell and gene therapies

• Main Authors: Will Thompson (Author), Eleftherios Terry Papoutsakis (Author)
• 格式: 圖書
• 出版: Wiley, 2023-09-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

Abstract Megakaryocytic extracellular vesicles (MkEVs) promote the growth and megakaryopoiesis of hematopoietic stem and progenitor cells (HSPCs) largely through endogenous miR‐486‐5p and miR‐22‐3p cargo. Here, we examine the impact of biomechanical force and culture age/differentiation on the forma...