Contribution of Chymase-Dependent Angiotensin II Formation to the Progression of Tubulointerstitial Fibrosis in Obstructed Kidneys in Hamsters

• Main Authors: Yu-Yan Fan (Author), Akira Nishiyama (Author), Yoshihide Fujisawa (Author), Hiroyuki Kobori (Author), Daisuke Nakano (Author), Junji Matsuura (Author), Naoki Hase (Author), Hirofumi Hitomi (Author), Hideyasu Kiyomoto (Author), Hidenori Urata (Author), Masakazu Kohno (Author)
• Format: Book
• Published: Elsevier, 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Recent studies indicate a role of chymase in the regulation of angiotensin II (AngII) formation in cardiovascular and renal tissues. We investigated a possible contribution of chymase to AngII formation and to renal fibrosis in unilateral ureteral obstruction (UUO). Eight-week-old Syrian hamsters we...