Comprehensive characterization of higher order structure changes in methionine oxidized monoclonal antibodies via NMR chemometric analysis and biophysical approaches

Comprehensive characterization of higher order structure changes in methionine oxidized monoclonal antibodies via NMR chemometric analysis and biophysical approaches

ABSTRACTThe higher order structure (HOS) of monoclonal antibodies (mAbs) is an important quality attribute with strong contribution to clinically relevant biological functions and drug safety. Due to the multi-faceted nature of HOS, the synergy of multiple complementary analytical approaches can sub...

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Main Authors: Mingyue Li (Author), Victor A. Beaumont (Author), Shahajahan Akbar (Author), Hannah Duncan (Author), Arch Creasy (Author), Wenge Wang (Author), Kelly Sackett (Author), Lisa Marzilli (Author), Jason C. Rouse (Author), Hai-Young Kim (Author)
Format: Book
Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
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