Integration of individual preclinical and clinical anti‐infective PKPD data to predict clinical study outcomes

• Main Authors: Vincent Aranzana‐Climent (Author), Wisse van Os (Author), Amir Nutman (Author), Jonathan Lellouche (Author), Yael Dishon‐Benattar (Author), Nadya Rakovitsky (Author), George L. Daikos (Author), Anna Skiada (Author), Ioannis Pavleas (Author), Emanuele Durante‐Mangoni (Author), Ursula Theuretzbacher (Author), Mical Paul (Author), Yehuda Carmeli (Author), Lena E. Friberg (Author)
• Format: Book
• Published: Wiley, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The AIDA randomized clinical trial found no significant difference in clinical failure or survival between colistin monotherapy and colistin-meropenem combination therapy in carbapenem‐resistant Gram‐negative infections. The aim of this reverse translational study was to integrate all indiv...