Similar Piperacillin/Tazobactam Target Attainment in Obese versus Nonobese Patients despite Differences in Interstitial Tissue Fluid Pharmacokinetics

• Main Authors: David Busse (Author), Philipp Simon (Author), David Petroff (Author), Christoph Dorn (Author), Lisa Schmitt (Author), Davide Bindellini (Author), Alexander Kratzer (Author), Arne Dietrich (Author), Markus Zeitlinger (Author), Wilhelm Huisinga (Author), Robin Michelet (Author), Hermann Wrigge (Author), Charlotte Kloft (Author)
• Format: Book
• Published: MDPI AG, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Precision dosing of piperacillin/tazobactam in obese patients is compromised by sparse information on target-site exposure. We aimed to evaluate the appropriateness of current and alternative piperacillin/tazobactam dosages in obese and nonobese patients. Based on a prospective, controlled clinical...