Identification of potent chemotypes targeting Leishmania major using a high-throughput, low-stringency, computationally enhanced, small molecule screen.

• Main Authors: Elizabeth R Sharlow (Author), David Close (Author), Tongying Shun (Author), Stephanie Leimgruber (Author), Robyn Reed (Author), Gabriela Mustata (Author), Peter Wipf (Author), Jacob Johnson (Author), Michael O'Neil (Author), Max Grögl (Author), Alan J Magill (Author), John S Lazo (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2009-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Patients with clinical manifestations of leishmaniasis, including cutaneous leishmaniasis, have limited treatment options, and existing therapies frequently have significant untoward liabilities. Rapid expansion in the diversity of available cutaneous leishmanicidal chemotypes is the initial step in...