The Cardioprotective Mechanism of Phenylaminoethyl Selenides (PAESe) Against Doxorubicin-Induced Cardiotoxicity Involves Frataxin

• Главные авторы: Xiaoyu Fu (Автор), Mathew Eggert (Автор), Sieun Yoo (Автор), Nikhil Patel (Автор), Juming Zhong (Автор), Ian Steinke (Автор), Manoj Govindarajulu (Автор), Emine Akyuz Turumtay (Автор), Shravanthi Mouli (Автор), Peter Panizzi (Автор), Ronald Beyers (Автор), Thomas Denney (Автор), Robert Arnold (Автор), Rajesh H. Amin (Автор)
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• Опубликовано: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Предметы: article
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Doxorubicin (DOX) is an anthracycline cancer chemotherapeutic that exhibits cumulative dose-limiting cardiotoxicity and limits its clinical utility. DOX treatment results in the development of morbid cardiac hypertrophy that progresses to congestive heart failure and death. Recent evidence suggests...