Reactivation of PPARα alleviates myocardial lipid accumulation and cardiac dysfunction by improving fatty acid β-oxidation in Dsg2-deficient arrhythmogenic cardiomyopathy

• Главные авторы: Yubi Lin (Автор), Ruonan Liu (Автор), Yanling Huang (Автор), Zhe Yang (Автор), Jianzhong Xian (Автор), Jingmin Huang (Автор), Zirui Qiu (Автор), Xiufang Lin (Автор), Mengzhen Zhang (Автор), Hui Chen (Автор), Huadong Wang (Автор), Jiana Huang (Автор), Geyang Xu (Автор)
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• Опубликовано: Elsevier, 2023-01-01T00:00:00Z.
• Предметы: article
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Arrhythmogenic cardiomyopathy (ACM), a fatal heart disease characterized by fibroadipocytic replacement of cardiac myocytes, accounts for 20% of sudden cardiac death and lacks effective treatment. It is often caused by mutations in desmosome proteins, with Desmoglein-2 (DSG2) mutations as a common e...