Reactivation of PPARα alleviates myocardial lipid accumulation and cardiac dysfunction by improving fatty acid β-oxidation in Dsg2-deficient arrhythmogenic cardiomyopathy

Arrhythmogenic cardiomyopathy (ACM), a fatal heart disease characterized by fibroadipocytic replacement of cardiac myocytes, accounts for 20% of sudden cardiac death and lacks effective treatment. It is often caused by mutations in desmosome proteins, with Desmoglein-2 (DSG2) mutations as a common e...

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Principais autores: Yubi Lin (Autor), Ruonan Liu (Autor), Yanling Huang (Autor), Zhe Yang (Autor), Jianzhong Xian (Autor), Jingmin Huang (Autor), Zirui Qiu (Autor), Xiufang Lin (Autor), Mengzhen Zhang (Autor), Hui Chen (Autor), Huadong Wang (Autor), Jiana Huang (Autor), Geyang Xu (Autor)
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Publicado em: Elsevier, 2023-01-01T00:00:00Z.
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