Melatonin Analogues Potently Inhibit MAO-B and Protect PC12 Cells against Oxidative Stress

• Main Authors: Ahmed Elkamhawy (Author), Jiyu Woo (Author), Noha A. Gouda (Author), Jushin Kim (Author), Hossam Nada (Author), Eun Joo Roh (Author), Ki Duk Park (Author), Jungsook Cho (Author), Kyeong Lee (Author)
• Format: Book
• Published: MDPI AG, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Monoamine oxidase B (MAO-B) metabolizes dopamine and plays an important role in oxidative stress by altering the redox state of neuronal and glial cells. MAO-B inhibitors are a promising therapeutical approach for Parkinson's disease (PD). Herein, 24 melatonin analogues (<b>3a</b>-&...