Exploring a New Generation of Pyrimidine and Pyridine Derivatives as Anti-Influenza Agents Targeting the Polymerase PA-PB1 Subunits Interaction

• Main Authors: Ilaria Giacchello (Author), Annarita Cianciusi (Author), Chiara Bertagnin (Author), Anna Bonomini (Author), Valeria Francesconi (Author), Mattia Mori (Author), Anna Carbone (Author), Francesca Musumeci (Author), Arianna Loregian (Author), Silvia Schenone (Author)
• Format: Book
• Published: MDPI AG, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The limited range of available flu treatments due to virus mutations and drug resistance have prompted the search for new therapies. RNA-dependent RNA polymerase (RdRp) is a heterotrimeric complex of three subunits, i.e., polymerase acidic protein (PA) and polymerase basic proteins 1 and 2 (PB1 and...