CCR9 Antagonists in the Treatment of Ulcerative Colitis

• Main Authors: Pirow Bekker (Author), Karen Ebsworth (Author), Matthew J. Walters (Author), Robert D. Berahovich (Author), Linda S. Ertl (Author), Trevor T. Charvat (Author), Sreenivas Punna (Author), Jay P. Powers (Author), James J. Campbell (Author), Timothy J. Sullivan (Author), Juan C. Jaen (Author), Thomas J. Schall (Author)
• Format: Book
• Published: Hindawi Limited, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

While it has long been established that the chemokine receptor CCR9 and its ligand CCL25 are essential for the movement of leukocytes into the small intestine and the development of small-intestinal inflammation, the role of this chemokine-receptor pair in colonic inflammation is not clear. Toward t...