In-Vitro and In-Vivo Evaluation of Velpatasvir- Loaded Mesoporous Silica Scaffolds. A Prospective Carrier for Drug Bioavailability Enhancement

• Main Authors: Yasir Mehmood (Author), Ikram Ullah Khan (Author), Yasser Shahzad (Author), Rizwan Ullah Khan (Author), Muhammad Shahid Iqbal (Author), Haseeb Ahmad Khan (Author), Ikrima Khalid (Author), Abid Mehmood Yousaf (Author), Syed Haroon Khalid (Author), Sajid Asghar (Author), Muhammad Asif (Author), Talib Hussain (Author), Shefaat Ullah Shah (Author)
• Format: Book
• Published: MDPI AG, 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The limited aqueous solubility of many active pharmaceutical ingredients (APIs) is responsible for their poor performance and low drug levels in blood and at target sites. Various approaches have been adopted to tackle this issue. Most recently, mesoporous silica nanoparticles (MSN) have gained atte...