Integration of a Physiologically Based Pharmacokinetic and Pharmacodynamic Model for Tegoprazan and Its Metabolite: Application for Predicting Food Effect and Intragastric pH Alterations

• Main Authors: Hyeon-Cheol Jeong (Author), Min-Gul Kim (Author), Zhuodu Wei (Author), Kyeong-Ryoon Lee (Author), Jaehyeok Lee (Author), Im-Sook Song (Author), Kwang-Hee Shin (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) model for tegoprazan and its major metabolite M1 was developed to predict PK and PD profiles under various scenarios. The PBPK model for tegoprazan and M1 was developed and predicted using the SimCYP^® simulator...