Enhancing Solubility and Dissolution Rate of Antifungal Drug Ketoconazole through Crystal Engineering

• Main Authors: Hongmei Yu (Author), Li Zhang (Author), Meiju Liu (Author), Dezhi Yang (Author), Guorong He (Author), Baoxi Zhang (Author), Ningbo Gong (Author), Yang Lu (Author), Guanhua Du (Author)
• Format: Book
• Published: MDPI AG, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To improve the solubility and dissolution rate of the BCS class II drug ketoconazole, five novel solid forms in 1:1 stoichiometry were obtained upon liquid-assisted grinding, slurry, and slow evaporation methods in the presence of coformers, namely, glutaric, vanillic, 2,6-dihydroxybenzoic, protocat...