Cover Image

Enhancing Solubility and Dissolution Rate of Antifungal Drug Ketoconazole through Crystal Engineering

To improve the solubility and dissolution rate of the BCS class II drug ketoconazole, five novel solid forms in 1:1 stoichiometry were obtained upon liquid-assisted grinding, slurry, and slow evaporation methods in the presence of coformers, namely, glutaric, vanillic, 2,6-dihydroxybenzoic, protocat...

Full description

Saved in:

Bibliographic Details
Main Authors:	Hongmei Yu (Author), Li Zhang (Author), Meiju Liu (Author), Dezhi Yang (Author), Guorong He (Author), Baoxi Zhang (Author), Ningbo Gong (Author), Yang Lu (Author), Guanhua Du (Author)
Format:	Book
Published:	MDPI AG, 2023-09-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Design, Preparation, Characterization and Evaluation of Five Cocrystal Hydrates of Fluconazole with Hydroxybenzoic Acids
by: Hongmei Yu, et al.
Published: (2022)

Investigation of possible solubility and dissolution advantages of cocrystals, I: Aqueous solubility and dissolution rates of ketoconazole and its cocrystals as functions of pH
by: Jaydip M. Vasoya, et al.
Published: (2019)

Two Novel Co-Crystals of Naproxen: Comparison of Stability, Solubility and Intermolecular Interaction
by: Cheng Xing, et al.
Published: (2022)

Improved Solubility and Dissolution Rates in Novel Multicomponent Crystals of Piperine with Succinic Acid
by: Erizal Zaini, et al.
Published: (2020)

Improvement of the Thermal Stability and Aqueous Solubility of Three Matrine Salts Assembled by the Similar Structure Salt Formers
by: Yeyang Wang, et al.
Published: (2024)

Role of Solvents in Improvement of Dissolution Rate of Drugs: Crystal Habit and Crystal Agglomeration
by: Maryam Maghsoodi
Published: (2015)

Improving the Dissolution Rate and Bioavailability of Curcumin via Co-Crystallization
by: Hao Wang, et al.
Published: (2024)

Engineering cocrystals of Paliperidone with enhanced solubility and dissolution characteristics
by: Radha-Rani Earle, et al.
Published: (2021)

Binary ethosomes for the enhanced topical delivery and antifungal efficacy of ketoconazole
by: Alhanouf A. Aljohani, et al.
Published: (2023)

Intrinsic Dissolution Rate Profiling of Poorly Water-Soluble Compounds in Biorelevant Dissolution Media
by: Alexandra Teleki, et al.
Published: (2020)

An impact of nanocrystals on dissolution rate of Lercanidipine: Supersaturation and crystallization by addition of solvent to antisolvent
by: Dolly Tulsibhai Gadhiya, et al.
Published: (2021)

Multicomponent cyclodextrin system for improvement of solubility and dissolution rate of poorly water soluble drug
by: Mayank Patel, et al.
Published: (2019)

Cilnidipine Nanocrystals, Formulation and evaluation for Optimization of solubility and Dissolution Rate
by: Suray A. Al Hazzaa, et al.
Published: (2023)

The Formulation and Characterization of Nimodipine Nanoparticles for the Enhancement of solubility and dissolution rate
by: Areej Wahhab Alhagiesa, et al.
Published: (2021)

Engineering Cocrystals of Poorly Water-Soluble Drugs to Enhance Dissolution in Aqueous Medium
by: Indumathi Sathisaran, et al.
Published: (2018)

Enhancement of Aqueous Solubility and Dissolution Rate of Etoricoxib by Solid Dispersion Technique
by: Mustapha M. AlKhalidi, et al.
Published: (2020)

Enhancement of Solubility and Improvement of Dissolution Rate of Atorvastatin Calcium Prepared as Nanosuspension
by: Ahmed H. Ali, et al.
Published: (2019)

Solubility, Permeability, and Dissolution Rate of Naftidrofuryl Oxalate Based on BCS Criteria
by: Marta Kus-Slowinska, et al.
Published: (2020)

Amiodarone hydrochloride: enhancement of solubility and dissolution rate by solid dispersion technique
by: Alexandre Machado Rubim, et al.
Published: (2015)

Two Novel Palbociclib-Resorcinol and Palbociclib-Orcinol Cocrystals with Enhanced Solubility and Dissolution Rate
by: Chenxin Duan, et al.
Published: (2021)

Enhancement of solubility and dissolution rate of poorly water soluble raloxifene using microwave induced fusion method
by: Payal Hasmukhlal Patil, et al.
Published: (2013)

Crystal Structure, Solubility, and Pharmacokinetic Study on a Hesperetin Cocrystal with Piperine as Coformer
by: Yanjie Liu, et al.
Published: (2022)

Insight into the Formation of Cocrystal and Salt of Tenoxicam from the Isomer and Conformation
by: Yifei Xie, et al.
Published: (2022)

Metformin-Mediated Improvement in Solubility, Stability, and Permeability of Nonsteroidal Anti-Inflammatory Drugs
by: Qi An, et al.
Published: (2024)

CRYSTAL FORMS OF LOMEFLOXACIN: PREPARATION, CHARACTERIZATION AND DISSOLUTION PROFILE
by: Vellaichamy Ganesan, et al.
Published: (2018)

Study the Antifungal and Ocular Permeation of Ketoconazole from Ophthalmic Formulations Containing Trans-Ethosomes Nanoparticles
by: Tarek A. Ahmed, et al.
Published: (2021)

Solubility and dissolution studies of tibolone polymorphs
by: Rudy Bonfilio, et al.
Published: (2018)

Enhancement of the Solubility and Dissolution Rate of Rebamipide by Using Solid Dispersion Technique (Part I)
by: Muna Y. Ismail, et al.
Published: (2018)

Development of a new ferulic acid certified reference material for use in clinical chemistry and pharmaceutical analysis
by: Dezhi Yang, et al.
Published: (2015)

Antifungal Susceptibility Testing to Determine Mic of Amphotericin B, Fluconazole and Ketoconazole Against Ocular Fungal Infection
by: Mitesh H. Patel, et al.
Published: (2011)

A novel formulation of ketoconazole entrapped in alginate with anionic polymer beads for solubility enhancement: Preparation and characterization
by: Viviane Annisa, et al.
Published: (2023)

Solid dispersions with hydrogenated castor oil increase solubility, dissolution rate and intestinal absorption of praziquantel
by: Marco Vinicius Chaud, et al.
Published: (2010)

Investigation of Crystallization and Salt Formation of Poorly Water-Soluble Telmisartan for Enhanced Solubility
by: Chulhun Park, et al.
Published: (2019)

Ketoconazole In The Treatment Of Eumycetoma
by: Bandyopadhyay Debabrata
Published: (1996)

Eumycetoma Treated With Ketoconazole
by: Mittal Radha Rani, et al.
Published: (1997)

Versatile Solid Modifications of Multicomponent Pharmaceutical Salts: Novel Metformin-Rhein Salts Based on Advantage Complementary Strategy Design
by: Mingchao Yu, et al.
Published: (2023)

Improved solubility, dissolution rate, and oral bioavailability of main biflavonoids from Selaginella doederleinii extract by amorphous solid dispersion
by: Bing Chen, et al.
Published: (2020)

Immediate-Release Nifedipine Binary Dry Powder Mixtures with Nanocellulose Featuring Enhanced Solubility and Dissolution Rate
by: Athanasios Mantas, et al.
Published: (2019)

A New Challenge for the Old Excipient Calcium Carbonate: To Improve the Dissolution Rate of Poorly Soluble Drugs
by: Valeria Ambrogi
Published: (2023)

Design of Etched- and Functionalized-Halloysite/Meloxicam Hybrids: A Tool for Enhancing Drug Solubility and Dissolution Rate
by: Valeria Friuli, et al.
Published: (2024)