Metformin Hydrochloride Significantly Inhibits Rotavirus Infection in Caco2 Cell Line, Intestinal Organoids, and Mice

• Main Authors: Rui Zhang (Author), Cui Feng (Author), Dandan Luo (Author), Ruibo Zhao (Author), Perumal Ramesh Kannan (Author), Yuebang Yin (Author), Muhammad Zubair Iqbal (Author), Yeting Hu (Author), Xiangdong Kong (Author)
• Format: Book
• Published: MDPI AG, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Rotavirus is one of the main pathogens that causes severe diarrhea in children under the age of 5, primarily infecting the enterocytes of the small intestine. Currently, there are no specific drugs available for oral rehydration and antiviral therapy targeting rotavirus. However, metformin hydrochlo...