Antibody-drug conjugates: Recent advances in linker chemistry

• Autores principales: Zheng Su (Autor), Dian Xiao (Autor), Fei Xie (Autor), Lianqi Liu (Autor), Yanming Wang (Autor), Shiyong Fan (Autor), Xinbo Zhou (Autor), Song Li (Autor)
• Formato: Libro
• Publicado: Elsevier, 2021-12-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Antibody-drug conjugates (ADCs) are gradually revolutionizing clinical cancer therapy. The antibody-drug conjugate linker molecule determines both the efficacy and the adverse effects, and so has a major influence on the fate of ADCs. An ideal linker should be stable in the circulatory system and re...