Antibody-drug conjugates: Recent advances in linker chemistry

• Main Authors: Zheng Su (Author), Dian Xiao (Author), Fei Xie (Author), Lianqi Liu (Author), Yanming Wang (Author), Shiyong Fan (Author), Xinbo Zhou (Author), Song Li (Author)
• Format: Book
• Published: Elsevier, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Antibody-drug conjugates (ADCs) are gradually revolutionizing clinical cancer therapy. The antibody-drug conjugate linker molecule determines both the efficacy and the adverse effects, and so has a major influence on the fate of ADCs. An ideal linker should be stable in the circulatory system and re...