Discovery of novel and potent CDK8 inhibitors for the treatment of acute myeloid leukaemia

• Main Authors: Zhuoying Chen (Author), Quan Wang (Author), Yao Yao Yan (Author), Dalong Jin (Author), Yumeng Wang (Author), Xing Xing Zhang (Author), Xin Hua Liu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

AbstractIt has been reported that CDK8 plays a key role in acute myeloid leukaemia. Here, a total of 40 compounds were rational designed and synthesised based on the previous SAR. Among them, compound 12 (3-(3-(furan-3-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide) showed the most potent inhibiting ac...