Relationship between hypoxia and downstream pathogenic pathways in preeclampsia

• Main Authors: Henri Augusto Korkes (Author), Leandro De Oliveira (Author), Nelson Sass (Author), Saira Salahuddin (Author), S. Ananth Karumanchi (Author), Augustine Rajakumar (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Defects in angiogenesis and mitochondrial function in the placenta contribute to the pathogenesis of preeclampsia; however upstream regulators of these pathways are not known. It has been argued that placental hypoxia secondary to abnormal spiral artery remodeling may play a causal role in the angio...