Benzo[g]quinazolin-based scaffold derivatives as dual EGFR/HER2 inhibitors

• Główni autorzy: Mostafa M. Ghorab (Autor), Mansour S. Alsaid (Autor), Aiten M. Soliman (Autor), Abdullah A. Al-Mishari (Autor)
• Format: Książka
• Wydane: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Targeting EGFR has proven to be beneficial in the treatment of several types of solid tumours. So, a series of novel 2-(4-oxo-3-(4-sulfamoylphenyl)-3,4-dihydrobenzo[g]quinazolin-2-ylthio)-N-substituted acetamide 5-19 were synthesised from the starting material 4-(2-mercapto-4-oxobenzo[g]quinazolin-3...