Structural Modifications Yield Novel Insights Into the Intriguing Pharmacodynamic Potential of Anti-inflammatory Nitro-Fatty Acids

• Main Authors: Nadine Hellmuth (Author), Camilla Brat (Author), Omar Awad (Author), Sven George (Author), Astrid Kahnt (Author), Tom Bauer (Author), Hai Phong Huynh Phuoc (Author), Dieter Steinhilber (Author), Carlo Angioni (Author), Mohamed Hassan (Author), Katharina J. Hock (Author), Georg Manolikakes (Author), Kai Zacharowski (Author), Jessica Roos (Author), Thorsten J. Maier (Author)
• Formato: Libro
• Publicado: Frontiers Media S.A., 2021-11-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Endogenous nitro-fatty acids (NFA) are potent electrophilic lipid mediators that exert biological effects in vitro and in vivo via selective covalent modification of thiol-containing target proteins. The cytoprotective, anti-inflammatory, and anti-tumorigenic effects of NFA in animal models of disea...