Pyrazole-Curcumin Suppresses Cardiomyocyte Hypertrophy by Disrupting the CDK9/CyclinT1 Complex

• Main Authors: Masafumi Funamoto (Author), Yoichi Sunagawa (Author), Mai Gempei (Author), Kana Shimizu (Author), Yasufumi Katanasaka (Author), Satoshi Shimizu (Author), Toshihide Hamabe-Horiike (Author), Giovanni Appendino (Author), Alberto Minassi (Author), Andreas Koeberle (Author), Maki Komiyama (Author), Kiyoshi Mori (Author), Koji Hasegawa (Author), Tatsuya Morimoto (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The intrinsic histone acetyltransferase (HAT), p300, has an important role in the development and progression of heart failure. Curcumin (CUR), a natural p300-specific HAT inhibitor, suppresses hypertrophic responses and prevents deterioration of left-ventricular systolic function in heart-failure m...