Pyrazole-Curcumin Suppresses Cardiomyocyte Hypertrophy by Disrupting the CDK9/CyclinT1 Complex

• मुख्य लेखकों: Masafumi Funamoto (लेखक), Yoichi Sunagawa (लेखक), Mai Gempei (लेखक), Kana Shimizu (लेखक), Yasufumi Katanasaka (लेखक), Satoshi Shimizu (लेखक), Toshihide Hamabe-Horiike (लेखक), Giovanni Appendino (लेखक), Alberto Minassi (लेखक), Andreas Koeberle (लेखक), Maki Komiyama (लेखक), Kiyoshi Mori (लेखक), Koji Hasegawa (लेखक), Tatsuya Morimoto (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2022-06-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The intrinsic histone acetyltransferase (HAT), p300, has an important role in the development and progression of heart failure. Curcumin (CUR), a natural p300-specific HAT inhibitor, suppresses hypertrophic responses and prevents deterioration of left-ventricular systolic function in heart-failure m...