Increased Frataxin Expression Induced in Friedreich Ataxia Cells by Platinum TALE-VP64s or Platinum TALE-SunTag

• 主要な著者: Khadija Cherif (著者), Catherine Gérard (著者), Joël Rousseau (著者), Dominique L. Ouellet (著者), Pierre Chapdelaine (著者), Jacques P. Tremblay (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2018-09-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Frataxin gene (FXN) expression is reduced in Friedreich's ataxia patients due to an increase in the number of GAA trinucleotides in intron 1. The frataxin protein, encoded by that gene, plays an important role in mitochondria's iron metabolism. Platinum TALE (plTALE) proteins targeting the...