Apremilast Microemulsion as Topical Therapy for Local Inflammation: Design, Characterization and Efficacy Evaluation

• Main Authors: Paulo Sarango-Granda (Author), Marcelle Silva-Abreu (Author), Ana Cristina Calpena (Author), Lyda Halbaut (Author), María-José Fábrega (Author), María J. Rodríguez-Lagunas (Author), Natalia Díaz-Garrido (Author), Josefa Badia (Author), Lupe Carolina Espinoza (Author)
• Format: Book
• Published: MDPI AG, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Apremilast (APR) is a selective phosphodiesterase 4 inhibitor administered orally in the treatment of moderate-to-severe plaque psoriasis and active psoriatic arthritis. The low solubility and permeability of this drug hinder its dermal administration. The purpose of this study was to design and cha...