Gellan gum-based mucoadhesive microspheres of almotriptan for nasal administration: Formulation optimization using factorial design, characterization, and in vitro evaluation

• Príomhchruthaitheoirí: Zaheer Abbas (Údar), Sachin Marihal (Údar)
• Formáid: LEABHAR
• Foilsithe / Cruthaithe: Wolters Kluwer Medknow Publications, 2014-01-01T00:00:00Z.
• Ábhair: article
• Rochtain ar líne: Connect to this object online.

Background: Almotriptan malate (ALM), indicated for the treatment of migraine in adults is not a drug candidate feasible to be administered through the oral route during the attack due to its associated symptoms such as nausea and vomiting. This obviates an alternative dosage form and nasal drug del...