Correlations between preclinical BJAB assay ranking of antisense drugs and clinical trial adverse events

• Main Authors: Wesley Partridge (Author), Sebastien A. Burel (Author), Annie Ferng (Author), Shuting Xia (Author), T. Jesse Kwoh (Author), Scott P. Henry (Author), Brenda F. Baker (Author)
• Format: Book
• Published: Wiley, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract This analysis sought to assess the clinical predictivity of an in vitro assay which utilized the human B‐lymphoma BJAB cell line, for identification of antisense oligonucleotides (ASOs) with the potential to elicit innate immune activation in humans. Adverse events (AEs) from clinical trial...