Snakebite drug discovery: high-throughput screening to identify novel snake venom metalloproteinase toxin inhibitors

• Main Authors: Rachel H. Clare (Author), Charlotte A. Dawson (Author), Adam Westhorpe (Author), Laura-Oana Albulescu (Author), Christopher M. Woodley (Author), Nada Mosallam (Author), Daniel J. W. Chong (Author), Jeroen Kool (Author), Neil G. Berry (Author), Paul M. O'Neill (Author), Nicholas R. Casewell (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Snakebite envenoming results in ∼100,000 deaths per year, with close to four times as many victims left with life-long sequelae. Current antivenom therapies have several limitations including high cost, variable cross-snake species efficacy and a requirement for intravenous administration in a clini...