Pharmacophore mapping: Prediction of BCR-ABL kinase inhibitory activity of α-benzylthio chalcones

In this investigation, 3D pharmacophore modeling studies were performed on a diverse set of 33 α-benzylthio chalcone derivatives that demonstrate anticancer activity by blocking BCR-ABL phosphorylation in leukemic cells. Pharmacophore modeling is based on the principle of the alignment of pharmacoph...

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Main Authors: Richa Bajaj (Author), Vikas Sharma (Author), Vipin Kumar (Author)
Format: Book
Published: Faculty of Pharmacy, Cairo University, 2014-06-01T00:00:00Z.
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3rd Floor Main Library

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