Pharmacophore mapping: Prediction of BCR-ABL kinase inhibitory activity of α-benzylthio chalcones

• Ngā kaituhi matua: Richa Bajaj (Author), Vikas Sharma (Author), Vipin Kumar (Author)
• Hōputu: Pukapuka
• I whakaputaina: Faculty of Pharmacy, Cairo University, 2014-06-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

In this investigation, 3D pharmacophore modeling studies were performed on a diverse set of 33 α-benzylthio chalcone derivatives that demonstrate anticancer activity by blocking BCR-ABL phosphorylation in leukemic cells. Pharmacophore modeling is based on the principle of the alignment of pharmacoph...