Nonlinear Mixed‐Effects Model Development and Simulation Using nlmixr and Related R Open‐Source Packages

• Main Authors: Matthew Fidler (Author), Justin J. Wilkins (Author), Richard Hooijmaijers (Author), Teun M. Post (Author), Rik Schoemaker (Author), Mirjam N. Trame (Author), Yuan Xiong (Author), Wenping Wang (Author)
• Format: Book
• Published: Wiley, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

nlmixr is a free and open‐source R package for fitting nonlinear pharmacokinetic (PK), pharmacodynamic (PD), joint PK‐PD, and quantitative systems pharmacology mixed‐effects models. Currently, nlmixr is capable of fitting both traditional compartmental PK models as well as more complex models implem...