Protocol of the IntenSify‐Trial: An open‐label phase I trial of the CYP3A inhibitor cobicistat and the cytostatics gemcitabine and nab‐paclitaxel in patients with advanced stage or metastatic pancreatic ductal adenocarcinoma to evaluate the combination's pharmacokinetics, safety, and efficacy

• Main Authors: Nicolas Hohmann (Author), Martin Ronald Sprick (Author), Moritz Pohl (Author), Azaz Ahmed (Author), Jürgen Burhenne (Author), Marietta Kirchner (Author), Lucian Le Cornet (Author), Markus Kratzmann (Author), Jacek Hajda (Author), Albrecht Stenzinger (Author), Karen Steindorf (Author), Stefan Delorme (Author), Heinz‐Peter Schlemmer (Author), Sabine Riethdorf (Author), Ron vanSchaik (Author), Klaus Pantel (Author), Jens Siveke (Author), Thomas Seufferlein (Author), Dirk Jäger (Author), Walter E. Haefeli (Author), Andreas Trumpp (Author), Christoph Springfeld (Author)
• Format: Book
• Published: Wiley, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Expression of CYP3A5 protein is a basal and acquired resistance mechanism of pancreatic ductal adenocarcinoma cells conferring protection against the CYP3A and CYP2C8 substrate paclitaxel through metabolic degradation. Inhibition of CYP3A isozymes restores the cells sensitivity to paclitaxe...