α-Ketoglutarate improves cardiac insufficiency through NAD+-SIRT1 signaling-mediated mitophagy and ferroptosis in pressure overload-induced mice

• Main Authors: Hao Yu (Author), Daojing Gan (Author), Zhen Luo (Author), Qilin Yang (Author), Dongqi An (Author), Hao Zhang (Author), Yingchun Hu (Author), Zhuang Ma (Author), Qingchun Zeng (Author), Dingli Xu (Author), Hao Ren (Author)
• Format: Book
• Published: BMC, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background In heart failure (HF), mitochondrial dysfunction and metabolic remodeling lead to a reduction in energy productivity and aggravate cardiomyocyte injury. Supplementation with α-ketoglutarate (AKG) alleviated myocardial hypertrophy and fibrosis in mice with HF and improved cardiac...