Safety and Reproducibility of a Clinical Trial System Using Induced Blood Stage Plasmodium vivax Infection and Its Potential as a Model to Evaluate Malaria Transmission.

• Main Authors: Paul Griffin (Author), Cielo Pasay (Author), Suzanne Elliott (Author), Silvana Sekuloski (Author), Maggy Sikulu (Author), Leon Hugo (Author), David Khoury (Author), Deborah Cromer (Author), Miles Davenport (Author), Jetsumon Sattabongkot (Author), Karen Ivinson (Author), Christian Ockenhouse (Author), James McCarthy (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Interventions to interrupt transmission of malaria from humans to mosquitoes represent an appealing approach to assist malaria elimination. A limitation has been the lack of systems to test the efficacy of such interventions before proceeding to efficacy trials in the field. We have previ...