Significance of Glioma Stem-Like Cells in the Tumor Periphery That Express High Levels of CD44 in Tumor Invasion, Early Progression, and Poor Prognosis in Glioblastoma

• Main Authors: Masahiro Nishikawa (Author), Akihiro Inoue (Author), Takanori Ohnishi (Author), Shohei Kohno (Author), Shiro Ohue (Author), Shirabe Matsumoto (Author), Satoshi Suehiro (Author), Daisuke Yamashita (Author), Saya Ozaki (Author), Hideaki Watanabe (Author), Hajime Yano (Author), Hisaaki Takahashi (Author), Riko Kitazawa (Author), Junya Tanaka (Author), Takeharu Kunieda (Author)
• Format: Book
• Published: Hindawi Limited, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glioblastoma multiforme (GBM) is the most aggressive malignant brain tumor and a subpopulation of glioma stem-like cells (GSCs) is likely responsible for the invariable recurrence following maximum resection and chemoradiotherapy. As most GSCs that are located in the perivascular and perinecrotic ni...