Expression of CYP3A4 mRNA Is Correlated With CYP3A4 Protein Level and Metabolic Activity in Human Liver

• Main Authors: Minoru Watanabe (Author), Toshio Kumai (Author), Naoki Matsumoto (Author), Masami Tanaka (Author), Satoshi Suzuki (Author), Tetsuo Satoh (Author), Shinichi Kobayashi (Author)
• Format: Book
• Published: Elsevier, 2004-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A relatively large amount of human liver tissue was required to determine the exact activity of human hepatic CYP3A. Although, the quantity of available human liver tissue samples is limited. We measured levels of CYP3A4 mRNA by RT-PCR with a radiolabeled primer specific for CYP3A4 and compared mRNA...