Genetic background modifies vulnerability to glaucoma-related phenotypes in Lmx1b mutant mice

• Автори: Nicholas G. Tolman (Автор), Revathi Balasubramanian (Автор), Danilo G. Macalinao (Автор), Alison L. Kearney (Автор), Katharine H. MacNicoll (Автор), Christa L. Montgomery (Автор), Wilhelmine N. de Vries (Автор), Ian J. Jackson (Автор), Sally H. Cross (Автор), Krishnakumar Kizhatil (Автор), K. Saidas Nair (Автор), Simon W. M. John (Автор)
• Формат: Книга
• Опубліковано: The Company of Biologists, 2021-02-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Variants in the LIM homeobox transcription factor 1-beta (LMX1B) gene predispose individuals to elevated intraocular pressure (IOP), a key risk factor for glaucoma. However, the effect of LMX1B mutations varies widely between individuals. To better understand the mechanisms underlying LMX1B-related...